Sex differences in glutathione metabolism and acetaminophen toxicity Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: What can I give my 2 year old to support his liver after having to unfortunately give Tylenol? TYLENOL [Acetaminophen APAP]why it may cause harm Tylenol should likely be avoided in excess by genetically vulnerable children. GENETICALLY VULNERABLE likely meanschildren with limited supplies of GLUTATHIONE. The problem with TYLENOL