Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. When Good Drugs Go Bad: Acetaminophen Toxicity tl;dr pharmacy Acetaminophen metabolism They told us Tylenol is safe. Pediatricians recommend them daily. But what if we've been missing the full story? Research shows that frequent use of acetaminophen (Tylenol) in babies and children