Can Tylenol (acetaminophen) deplete glutathione levels in the body? NAcetylcysteine (NAC) is More Than Just an Antidote. NAC replenishes glutathione (GSH), breaks mucus disulfide bonds, and modulates glutamate. That's why it works in the liver, lungs, and brain. Owais Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA When Tylenol (acetaminophen) is not properly metabolized, it creates a toxic biproduct. The process to metabolize acetaminophen is called glucuronidation. This process is underdeveloped in young babies.