What is BPC 157 and How Can It Benefit You? Le Jolie Med Spa Some people start seeing improvements with as little as 250 micrograms once per day, while others need to work up to around 1 to 2 milligrams daily, split into smaller doses on an empty stomach. In BPC157 & TB500 Blend (10mg 10mg) 99%+ Purity, COA Verified People talk about BPC 157 like it's one thing. It isn't. Oral BPC 157 stays local. It survives digestion long enough to act on the GI mucosa, then clears before it reaches systemic circulation.